This study was conducted to measure the time course of alveolar-capillary uptake rate of these volatile agents using the direct Fick method, and results of this study from 28 of these patients were previously published. With institutional review board approval (METC97/114 A/mF, 1997), the first series was conducted at Catharina Hospital, Eindhoven, The Netherlands, and Onze-Lieve-Vrouw (OLV) Hospital, Aalst, Belgium, from 1997 to 2000, and recruited 32 patients who were sequentially allocated to receive maintenance phase inhalational general anesthesia with halothane (n = 11), sevoflurane (n = 11), or isoflurane (n = 10). In both series, data were obtained from patients undergoing elective cardiac or thoracic aortic surgery, with no history of acute or chronic respiratory disease, who were recruited with written informed patient consent.
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